AMD related to Kidney disease
AMD related to kidney disease? A new study finds a relationship between serum cystatin C level (a measure of kidney function) and chronic kidney disease (defined by glomerular filtration rate) with the incidence of AMD.
The finding of a relationship of complement factor H Y402H (1277T->C) genotype status to both age-related macular degeneration (AMD) and kidney disease has led to speculation that kidney disease might be associated with AMD. Furthermore, many factors associated with chronic kidney disease such as oxidative stress, inflammation, and endothelial dysfunction have been hypothesized to have a role in the pathogenesis of AMD.
Cystatin C is abundant in retinal pigment epithelium (RPE) cells and has been hypothesized to have a role in the pathogenesis of AMD. Cystatin C is an inhibitor of cysteine proteinases (known as cathepsins). It has been hypothesized that cathepsins are involved in the pathogenesis of AMD. Data from cell culture and animal studies suggest that cathepsins may maintain homeostasis of the retinal photoreceptors and the extracellular environment of the Bruch membrane. The deleterious effect of a high serum cystatin C concentration is postulated to be due to its reduction of the protective effect of cathepsins. Inhibition of cathepsins increases the release of antineogenic endostatins from Bruch membrane, resulting in higher risk of exudative AMD. Serum levels of cystatin C tend to be higher in persons with impaired kidney function.
This research analyzed data from the Beaver Dam Eye Study, a population-based study of 4926 residents of Beaver Dam, Wisconsin that were aged 43 to 86 years at baseline. AMD was determined by grading photographs of the macula. The level of serum cystatin C was determined using a nephelometer. Individuals were defined as having mild or moderate to severe chronic kidney disease based on a glomerular filtration rate of more than 45 mL/min/1.73 m2 to 60 mL/min/1.73 m2 or less and 45 mL/min/1.73 m2 or less, respectively, according to the Modification of Diet in Renal Disease Study equation.
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While controlling for age and other risk factors, the level of serum cystatin C at baseline was associated with the 15-year cumulative incidence of early AMD (odds ratio: 1.16) and exudative AMD (1.42) but not geographic atrophy (0.89) or progression of AMD (1.02). Mild chronic kidney disease (defined by glomerular filtration rate) was associated with the 15-year cumulative incidence of early AMD (odds ratio: 1.36) but not the incidence of other AMD end points.
The researchers found that when controlling for age, sex, smoking status, and other risk factors, a higher level of serum cystatin C was associated with increased risk of incident early AMD and exudative AMD. The effect was stronger for incident exudative AMD in individuals without chronic kidney disease compared with those with chronic kidney disease, which suggests that this relationship might not be due to kidney-related processes. They also found a statistically significant relationship of mild chronic kidney disease (defined by glomerular filtration rate) with the incidence of early AMD but not with exudative AMD, geographic atrophy, or progression of AMD. The underlying biological processes responsible for these findings remain to be determined.
The investigators conclude that there is a relationship between the level of serum cystatin C and chronic kidney disease with the incidence of AMD.
Sunday, August 14, 2011
Intake of citrus fruits—prevents Kidney stones. Really
Kidney stones strike more than a million Americans every year. Sometimes, it causes hurting to bring them factually to their knees.
Along with medication to dampen the formation of kidney stones, fatalities are often buoyant to make nutritional changes, among them intake of more citrus juices. Citrate in the fruit juices often reduces the creation of calcium oxalate stones and also lowers urine acidity, almost like the kidney stone prescription potassium citrate.
Kidney stones strike more than a million Americans every year. Sometimes, it causes hurting to bring them factually to their knees.
Along with medication to dampen the formation of kidney stones, fatalities are often buoyant to make nutritional changes, among them intake of more citrus juices. Citrate in the fruit juices often reduces the creation of calcium oxalate stones and also lowers urine acidity, almost like the kidney stone prescription potassium citrate.
Thursday, July 28, 2011
Kidney failure is also known by chronic renal failure and end stage renal disease. The kidney failure disease occurs when metabolism produces and rapidly increases in the body. These products are harmful for body and liver filters some toxin when it comes in body for breathing then these products again get filtered and expelled as urine. Thus, those toxins get accommodated on the liver and kidney. Kidney started to anomaly in working and it become dangerous for kidney so the result, kidneys are not able to work properly and this stage is known as kidney failure.
Symptoms of kidney failure
The symptoms of kidney failure are given below-
1. Digestion of food is not well that means food can not be digested completely.
2. Vomit occurs after eating because liver is not able to digest food.
3. Swelling in foot or feet and heavy pain occurs in it.
4. Some time pain occurs in back and stomach.
5. Change in urination is the big symptom of kidney failure.
6. Short breathing is started because heart is also affected by that harmful product.
7. Itching in body because blood circulation got slow due to blood pumping by heart already got slow by that harmful products.
These are the main symptoms which are definitely shown in kidney failure patients. Some time kidney is also affected by nutrients or large use of nutrients. Generally kidney is affected by protein because this nutrient presents in mostly food and vegetable.
Causes of kidney failure
The causes which are responsible for kidney failure are given below-
1. Use of Nicotine, Smocking, Alcohol etc. these things are very harmful for human body.
2. More use of nutrients is also harmful for body.
3. Poor intake of fluid means when blood circulation got slow then the fluid which is produces by body is also got slow then result swelling in foot.
4. Problem occurs during urination.
5. More use of oily food.
These are the common reasons due to kidney failure possible but for preventing from kidney failure some diet tips are also given below.
Diet tips for kidney failure patients
There are some tips are here which helps in kidney failure diet-
1. Eat healthy food like green vegetables, corns, pulses etc.
2. Take nutrients in similar manner means don’t take any nutrients in more amounts.
3. Eat balance amount of protein like fish, chicken, meet etc.
4. Much amount of potassium is dangerous for body so avoid more use of salt.
5. Avoid heavy drink because liquid is quickly gone to the kidney and kidney is not able to filter for urine and due to it tissues of body got swelled.
6. Avoid more use of milk, cheese, butter, oil and those things in which oil is presented.
Treatment for kidney failure
There are many treatments available for kidney failure but it is possible until kidneys are not destroyed totally. So it is necessary that if you feel any symptoms from these so quickly go to the doctor and do check-up for conform it.
1. Dialysis is the treatment for kidney failure but doctors suggest you that you need of it or not.
2. Kidney transplant is the treatment when your kidney is totally destroyed and not able to work.
Home remedy for kidney failure
1. Burdock: – By use of burdock you can do treatment of kidney failure. Take one table spoon of dry powdered burdock and boil it with one glass of water for 5 minutes and then drink this water daily 3 times in a day.
2. Cucumber: – Cucumber is a very useful thing which helps in treatment of kidney failure and it also easily available in the market. Take it daily with food as salad.
• Botanic Choice Ultra Kidney Complex Capsules, 60-Count Bottle
• Native Remedies Kidney Doctor, 50 ml
• Kidney Well II – Concentrated Herbal Blend – Dietary Supplement
• Balanceuticals NephroEase Dietary Supplement Capsules, 500 mg, 60-Count Bottle
• “Special” Kidney Mix Tea
• Renatrophin PMG (90 Tablets)
• Phyto & Antioxidant (100 Capsules) – Concentrated Herbal Blend – Dietary Supplement
Thursday, June 23, 2011
Tuesday, May 17, 2011
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